qemu
Install MS-DOS 6.22 on MacOS with QEMU
qemu-img create -f qcow msdos.disk 2G # create image for virtual harddisk
qemu-system-i386 -hda msdos.disk -m 64 -L . -fda dos622_1.img -boot a
during install when asked for next diskette: Ctrl+Alt+2
to go to qemu shell:
eject floppy0 # or fd0? In case you don't know the name type `info block`.
change floppy0 disk2.img
press Ctrl+Alt+1
to go back to installer and finish setup.
after installation you can start qemu with the msdos.disk as follows:
qemu-system-i386 -hda msdos.disk -m 64 -L .